Symbol
Name
ID

Fos
FBJ osteosarcoma oncogene
MGI:95574

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

increased macrophage apoptosis

abnormal osteoclast differentiation

abnormal thymus size

decreased thymocyte number

abnormal lymphopoiesis

decreased double-positive T cell number

increased granulocyte number

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased T cell number

decreased osteoclast cell number

abnormal spleen morphology

abnormal spleen white pulp morphology

decreased splenocyte number

abnormal macrophage physiology

increased macrophage cytokine production

increased circulating interleukin-10 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal cytokine secretion

decreased interleukin-10 secretion

increased interleukin-6 secretion

increased tumor necrosis factor secretion

increased susceptibility to endotoxin shock

skin inflammation

increased susceptibility to bacterial infection

Availability

Mouse Genotype

Fos^tm1Pa/Fos^tm1Pa

Fos^tm1Wag/Fos^tm1Wag

Fos^tm3.1Wag/Fos^tm3.1Wag

Fos^tm4.1Wag/Fos^tm4.1Wag

Fos^tm5.1Wag/Fos^tm5.1Wag

Fos^tm6.1Wag/Fos^tm6.1Wag

Col1a1^{tm1(tetO-Fos)Wag}/Col1a1⁺
Tg(KRT5-rtTA)T2D6Sgkd/0

Fos^tm7Wag/Fos^tm7Wag
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Fos^tm7Wag/Fos^tm7Wag
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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